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compusyn synergy software  (ComboSyn Inc)
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ComboSyn Inc compusyn synergy software
HDAC inhibitor (TSA) and BRD4 inhibitor (JQ1) are potent suppressors of early passage PDA primary cells. Primary mouse PDA cells of increasing passage number (10, 50, 100) were treated with increasing concentrations (1, 25, 50, 100, 200, 400, 800, 1600 nM) of ( A ) TSA or ( B ) JQ1 for 72 h. Cell viability was measured by Resazurin sodium salt assay. Data are expressed as Mean ± SEM from three independent experiments. ( C ) Primary mouse PDA cells were treated with increasing concentrations of JQ1 at three concentrations of TSA (25, 50, or 100 nM) for 72 h. Cell viability at sub uM concentrations of JQ1 significantly decreased with increasing [TSA]. Data are shown as Mean ± SEM from two independent experiments. ( D ) Combination index (CI) analysis showed synergistic effects for combined TSA + JQ1. The line at CI = 1 indicates additivity; data points below indicate synergy. Synergy with JQ1 increased at higher concentrations of TSA. ( E ) EC 50 of JQ1 at three concentrations of TSA (25, 50, or 100 nM). Graphpad Prism v7 software [ https://www.graphpad.com/ (current version); licensed] and <t>CompuSyn</t> ( https://www.combosyn.com/ ; publicly available) were used for data analysis and visualization.
Compusyn Synergy Software, supplied by ComboSyn Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compusyn synergy software - by Bioz Stars, 2026-03
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HDAC inhibitor (TSA) and BRD4 inhibitor (JQ1) are potent suppressors of early passage PDA primary cells. Primary mouse PDA cells of increasing passage number (10, 50, 100) were treated with increasing concentrations (1, 25, 50, 100, 200, 400, 800, 1600 nM) of ( A ) TSA or ( B ) JQ1 for 72 h. Cell viability was measured by Resazurin sodium salt assay. Data are expressed as Mean ± SEM from three independent experiments. ( C ) Primary mouse PDA cells were treated with increasing concentrations of JQ1 at three concentrations of TSA (25, 50, or 100 nM) for 72 h. Cell viability at sub uM concentrations of JQ1 significantly decreased with increasing [TSA]. Data are shown as Mean ± SEM from two independent experiments. ( D ) Combination index (CI) analysis showed synergistic effects for combined TSA + JQ1. The line at CI = 1 indicates additivity; data points below indicate synergy. Synergy with JQ1 increased at higher concentrations of TSA. ( E ) EC 50 of JQ1 at three concentrations of TSA (25, 50, or 100 nM). Graphpad Prism v7 software [ https://www.graphpad.com/ (current version); licensed] and CompuSyn ( https://www.combosyn.com/ ; publicly available) were used for data analysis and visualization.

Journal: Scientific Reports

Article Title: Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics

doi: 10.1038/s41598-020-77373-8

Figure Lengend Snippet: HDAC inhibitor (TSA) and BRD4 inhibitor (JQ1) are potent suppressors of early passage PDA primary cells. Primary mouse PDA cells of increasing passage number (10, 50, 100) were treated with increasing concentrations (1, 25, 50, 100, 200, 400, 800, 1600 nM) of ( A ) TSA or ( B ) JQ1 for 72 h. Cell viability was measured by Resazurin sodium salt assay. Data are expressed as Mean ± SEM from three independent experiments. ( C ) Primary mouse PDA cells were treated with increasing concentrations of JQ1 at three concentrations of TSA (25, 50, or 100 nM) for 72 h. Cell viability at sub uM concentrations of JQ1 significantly decreased with increasing [TSA]. Data are shown as Mean ± SEM from two independent experiments. ( D ) Combination index (CI) analysis showed synergistic effects for combined TSA + JQ1. The line at CI = 1 indicates additivity; data points below indicate synergy. Synergy with JQ1 increased at higher concentrations of TSA. ( E ) EC 50 of JQ1 at three concentrations of TSA (25, 50, or 100 nM). Graphpad Prism v7 software [ https://www.graphpad.com/ (current version); licensed] and CompuSyn ( https://www.combosyn.com/ ; publicly available) were used for data analysis and visualization.

Article Snippet: CompuSyn synergy software ( https://www.combosyn.com/ ; publicly available) based on the drug combination principles of Chou-Martin was used for combination index (CI) values quantification.

Techniques: Software

Gemcitibine (Gem) cytotoxicity in PDA primary cells is potentiated by combined TSA and JQ1. ( A ) Primary mouse PDA cells were treated with Gem alone or increasing concentrations of Gem and two concentrations (50 or 100 nM) of TSA or JQ1 or ( B ) combination of Gem + TSA + JQ1 for 72 h. Cell viability was measured by Resazurin sodium salt assay. Data are shown as Mean ± SEM from three independent experiments. ( C ) Combination index (CI) analysis was performed to identify synergistic effects for the drug combinations in ( C ). The dotted line at CI = 1 indicates additivity; data points below indicate synergy. ( D ) EC 50 of Gem at different concentrations of TSA + JQ1. Graphpad Prism v7 software ( https://www.graphpad.com/ (current version); licensed) and CompuSyn ( https://www.combosyn.com/ ; publicly available) were used for data analysis and visualization.

Journal: Scientific Reports

Article Title: Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics

doi: 10.1038/s41598-020-77373-8

Figure Lengend Snippet: Gemcitibine (Gem) cytotoxicity in PDA primary cells is potentiated by combined TSA and JQ1. ( A ) Primary mouse PDA cells were treated with Gem alone or increasing concentrations of Gem and two concentrations (50 or 100 nM) of TSA or JQ1 or ( B ) combination of Gem + TSA + JQ1 for 72 h. Cell viability was measured by Resazurin sodium salt assay. Data are shown as Mean ± SEM from three independent experiments. ( C ) Combination index (CI) analysis was performed to identify synergistic effects for the drug combinations in ( C ). The dotted line at CI = 1 indicates additivity; data points below indicate synergy. ( D ) EC 50 of Gem at different concentrations of TSA + JQ1. Graphpad Prism v7 software ( https://www.graphpad.com/ (current version); licensed) and CompuSyn ( https://www.combosyn.com/ ; publicly available) were used for data analysis and visualization.

Article Snippet: CompuSyn synergy software ( https://www.combosyn.com/ ; publicly available) based on the drug combination principles of Chou-Martin was used for combination index (CI) values quantification.

Techniques: Software